ScienceCostTweaker increases the difficulty and the amount of stuff needed.
Especially gold is a hurdle in that phase, where you start blue science, because you don't have the pure sorting recipe from crystals. I would recommend to prioritize this research. You also need those 3 different acids to create the crystals.
Until that, you have rubyte chunks, which create an awful lot of lead ore, which will be consumed eventually.
But dont worry, it'll get more insane
EDIT: Seablock is not only about complexity like a normal B&A run, but also about mass production and throughput like vanilla