This occurs when "focusing" a window other than factorio (selecting it) and when "focusing" factorio when another window was selected. It does not happen when "Use flip presentation model" is disabled. It also does not happen when "Use flip presentation model" is enabled and OBS is recording with a source of the 4k monitor (but does occur when the source is another monitor).
Graphics Settings:
![Image](https://forums.factorio.com/images/ext/9d444b1873575ac3250e13de43fda63f.png)
Hardware:
GPU: AMD 270x 2gb
CPU: Intel i7-7700