Assuming you have a 2x2 nuclear (neighbour bonus) which you want to run with a 50% duty cycle and steam storage. You need 80MW worth of fuel to power it. Each fuel cell is 8GJ so you need a fuel cell every 8GJ/80MW = 100 seconds. I'm ignoring the fact that the minimum runtime is 200s as it impacts your steam storage not ore consumed.
<edit=cbhj1>One U235 makes 10 fuel cells so you only need 1 per 1000 seconds</edit>
Ignore U238 since it is plentiful. You need one U235 every 1000 seconds from your centrifuges. To get one you need to process, on average, 10/0.007 = 1428.6 ore or let's say 1500. It takes 10 seconds to process 10 ore so 1500 seconds to process the ore to get one U235. If you want that every 1000 seconds you need to be running 1.5 centrifuges. The ore also has to be mined at a rate of 0.525 per drill so to get 1428.6 / 0.525 = 2721 so at the required rate of 100/s you need 2.8 drills.
Results for the power only
With optimal steam storage and fuel loading a 2x2 reactor on a 50% duty cycle produces 40*4*3/2 = 240MW
To feed it you need 1.5 centrifuges and 2.8 miners
Alongside this you'll need to get Kovarex running which takes 40 U235. Getting there takes 40*10/0.007 = 57K Uranium ore.
To feed into the Kovarex process you'll need centrifuges and miners. If you have the same number 1.5 centrifuges and 2.8 miners then you'll need 57K for Kovarex and 57K for Nuclear power.
Results
If you want 240MW and you are willing to build 3 centrifuges and 5.6 miners you can get Kovarex up and running while also generating power if your available ore exceeds 114K.
Consider starting up your powerplant before you've acquired your 40 U235 Kovarex stash. Doesn't take many drills or centrifuges to run a decent powerplant.