Have you at any time manually changed values in the %appdata%\Factorio\config\config.ini ?
A value is set to "auto" (with quotes), but should be set to auto (without quotes).

If you don't know what I'm talking about then just try deleting the config.ini file. This will also reset all your settings ...

I have uninstalled the game numerous of times and installed it in both my C: an E: drive. But neither seems to help.

Here is my system specs:
Processor: AMD A10-7870K Radeon R7, 12 Compute Cores 4C+8G
Video Card: NVIDIA GeForce GTX 970
RAM: 10 GB
OS: Windows 7 Home Premium 64-bit