Actually, looks like I can reproduce only by deconstructing the miniloaders; Has something to do with the link between the miniloaders and the splitter. Workaround is to deconstruct everything on both sides of the miniloaders prior to deconstructing the loaders themselves.

I've hit a crash that I suspect is the same: Version: 16.16 build 34924 Log, save, mods, dump, dxdiag: https://www.dropbox.com/sh/3mvjk2t76r7wsfl/AABsJUJ6tD7CYFWPIzIzok3ka?dl=0 Steps to reproduce: 1. Deconstruct (right-click) the two MiniLoaders in front of a splitter (such as the ones in the red bo...

Well, I managed to get back into the state again once and noticed a few things: - Changing quality settings in Factorio had no effect - Disabling just the left monitor had no effect - Disabling GSync on the primary monitor decreased the stuttering, but did not remove it completely - Switching primar...

I just realized I never tried disabling high quality graphics when it happens. I'll give that a shot next time for sure. Maybe there's some kind of VRAM management bug...

Does OP or anybody else who experiences this use multiple monitors on a GeForce card? I noticed that OP is a Twitch streamer, so multiple monitors seems likely. I may or may not be experiencing the same problem: Most of the time, Factorio runs fine. I can play for 10+ hours with a very large base in...