It seems to happen when I:
- Use cliff explosives to clear the cliffs that are marked for deconstruction. Can be done using three explosives.
- Build rails over the ghosts that have already been placed.
- Build signals where the intersections are.
Here is the log from my latest game, it's unusually unfinished: https://pastebin.com/PqbJN5Wq I saved the game just before trying to place the signals.
Here is an image (Night time) of my rail and signal placement just before the crash:
You can see the holes from the cliff explosives I used earlier. Three of them are on or close to rails, the fourth is just using my last explosive.
So... If the game keeps crashing when I'm trying to build/'grow my factory'... It's literally just unplayable.