I got slowdowns on both an external display 2560x1440 and internal display 1792 x 1120. Slowdown sometimes happened both in fullscreen & windowed.
I played around with a bit more in windowed mode. In some scenes the FPS will swap between ~10 and 60 based on an absolutely tiny window size change, probably 10 pixels difference in window size and it's difference between solid 60 and completely unplayable lagfest.
I realized that I was on older macos release, Sonoma. I updated to Sequoia the performance is much better and doesn't seem to lag nearly as badly!
Or maybe result of the SDL update? edit: nope I'm still on 2.0.15
I guess Sequoia ships with newer GPU driver.
Still need "Render in native screen resolution", and same kind of lag spikes do seem to happen sometimes. But not nearly as frequently or for as long.
Specific menu previews that were super laggy now seem ok most of the time.