If I drop the sprite resolution down to normal, it seems problem is gone. But I was running high resolutions sprites since 0.15 came out and the problem first appeared in 0.15.10

0.004 2017-05-21 14:02:03; Factorio 0.15.12 (build 29834, mac, alpha)
0.006 Operating system: Mac OS X 10.12.6
0.007 Program arguments: "/Applications/factorio.app"
0.007 Read data path: /Applications/factorio.app/Contents/data
0.007 Write data path: /Users/mylan/Library/Application Support ...

Hi,
I'm running macOS and since version 0.15.10 game is flickering a lot and skipping frames. Until version 0.15.9 there were some graphic glitches, but since 0.15.10 game became unplayable, especially when going out of the base and seeing lot of biters, or too many bots flying around (I have tried ...

Just update to 0.15.10 a got the same issue on mac. Game crashes during startup (41% Loading sprites...)
0.001 2017-05-12 21:41:33; Factorio 0.15.10 (build 29654, mac, alpha)
0.001 Operating system: Mac OS X 10.12.5
0.001 Program arguments: "/Applications/factorio.app" "-psn_0_14011740"
0.001 ...