Raum, et al,
Thanks for the analysis, and Raum I suspected the same type of thing. Thanks for digging up some resources.

One crazy thing today...I booted up, and first thing I used IE to read this forum post, and through a combination of hitting "Reply", realizing I wasn't logged in, and then ...

McAfee, provided by the Department of Defense for home use - definitions up to date. Let me see if I can disable it after playing and then try secure web connections again.

Edit: Disabled McAfee Firewall and Realtime protection (the only two settings I could effect), with no change (still couldn't ...

Tech Specs:
Alienware A-51-R2
Intel Core i7, 3.30GHz
16GB
dual NVIDIA GeForce GTX 780's (2x DVI outputs from the computer...no HDMI connections.)
Windows-10 Pro 64

Actions taken to duplicate this problem today (from power-up):
Launch Factorio (thru Steam), Load Game (single player), save game, then ...

Every time I exit the game, I lose the ability to access secure webpages (https:). I check Internet Options, and all of my SSL, etc. settings are unchanged.
A reboot fixes the problem.

If I am streaming Netflix, etc. on my second monitor, the current movie or show will finish (it doesn't cut off ...