Of all the aspects in Factorio, the one I dislike the most is mining-expansion. Resources keep running out and I have to rush out and perform the same thing, over and over again:

1) Explore the area to find resources
2) Fight and clear any hives on the way (when impossible to avoid)
3) Create a ...

When the base gets to a certain size, it is hard to keep track of production.

Every now and then something harms my production and it takes a while before I discover it: Ore runs out, a biter destroys a single pipe, I tweak something without realizing the effect it will have on the rest of the base ...