To reproduce is unlikely. Hardware issue that might be, yes.

Was playing for several hours straight, designing a new setup on Vulcanus. Clicked on empty tile (on refined concrete) and got crash. It's first time in 1000+ hours and it didn't reproduce again yet.

I've just stumbled upon this article:
https://devblogs.microsoft.com/engineering-at-microsoft/copy-on-write-in-win32-api-early-access/

I've no idea what they are talking about but it talks about Copy-on-Write in Windows, which was mentioned here as a requirement for non-blocking-saving to work. Any ...