Following up on my last message, I tried downloading the game directly from the Factorio website, deleting the ~/Library/Application Support/factorio folder, and the game still crashes with the steps of:

1) Opening up Factorio (skip past the "enter username and password" dialog)
2) Creating a new ...

I also have this issue. I tried entirely deleting the ~/Library/Application Support/factorio folder, reinstalling the game, and restarting my computer, and I can still reproduce the issue by:
1) Opening up Factorio
2) Creating a new game
3) Immediately pressing esc and clicking the save game button ...