I've got the same issue. It really looks like VSync is not applied. It worked a week ago or so. Seems to be caused by the new version.
Toggling VSync on or off does not change anything. Anything else I can try?
Is there an easy way to downgrade factorio with Steam?

I cannot change the setting in-game because it hangs during startup. I looked at ~/Library/Application Support/factorio/config/config.ini but found no stream-from-disk. I added stream-from-disk=false to the end and it still hangs at 95% "Loading Sounds". Got back to the ini file and noticed that I ...

I have the same issue on MacOS. Hangs always when starting. Seems to be lock related. Here are all stacks of all threads:

Sampling process 2018 for 3 seconds with 1 millisecond of run time between samples
Sampling completed, processing symbols...
Analysis of sampling factorio (pid 2018) every 1 ...