No, changing sprite resolution to Normal doesn't change anything.

It looks like the time is being spent in draw-engine and Flip[off] (whatever that means)
https://cdn.discordapp.com/attachments/883531947664617502/940727250465222746/Screenshot_from_2022-02-08_22-51-36.png
https://cdn.discordapp ...

Well, my laptop isn't a particularly powerful one (Ryzen 2500U with integrated Vega 8) and while trying to play Factorio on a 4K screen I noticed that the game runs better when camera is zoomed out. This is kinda weird - from my understanding, while zoomed in, the game has to render less items, so ...