using Win8 compatibility mode seems to work. Win7 comp.mode not possible due to required SP1.
So there's a problem with Win10 on my rig and Factorio.

Crashes occur on entering map, closing hints or within 1 or 2 minutes. Longest play was walking to copper spot and placing drill.
latest released Factorio version (as of 03-07) and experimental.
System Specs:

SiSoftware Sandra

Nr
Hostname : Sleipnir
Arbeitsgruppe : WORKGROUP

System
Modell : ASUS ...