For your reference I found it was my anti-virus EmsiSoft flagging Factorio as a code-injector when I tried to change mods, i was able to set it to ignore the executable.

Okay thanks

It prevents me from changing the mods or deleting them since it doesn't restart after I click confirm 0.002 2021-04-28 22:20:36; Factorio 1.1.32 (build 58364, win64, steam) 0.002 Operating system: Windows 10 (version 2004) 0.002 Program arguments: "F:\SteamLibraryWork\steamapps\common\Factorio\...