It happened twice now and I think I know what's going on - while the game is running on my main screen in 1080p, the second screen is an old 1600x1200 one. When I turn both screens off and back on, Windows (10) does its thing with moving desktop icons around and playing the "new hardware connected" jingle depending on which screen gets turned on first.
This only occurs if the game window is active and maximized though - not an issue if I minimize it first
(because I doubt my 1080Ti is actually running out of vmem
)Keep up the good work
