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I have been playing my latest save for 17 hours and have encountered a deserialization error just now.
I noticed the numbers on my toolbar were flickering (one of them was changing to "@" and back again, others did different things) so I saved and wanted to reload to see if it was still there. When I went to load the game I encountered this error:
"Deserialization error, target with id 280 doesn't exist"

I started this save on 0.10.0 with the mods Landfill & Shotgunfix. I have updated Landfill to 0.10 by replacing all references to .wav to .ogg

Latest working autosave was 04:19 earlier, the autosaves 02:19 and 00:19 earlier were giving the same error.

The first corrupt autosave:
Google Drive download
The last working autosave:
Google Drive download

Between the latest working autosave (-04:19) and the corrupt one (-02:19) I had deployed one of the station blueprints I have (without corners), placed some rails and ran back to base to get supplies.

I'm running the x64 windows version on an i7 2700k, gtx 580 3gb, 8gb 1600 ram.

If there's anything else I can supply, please let me know.

Thanks for the report. The problem is somehow related to the rails (or rail in a blueprint). You wouldn't be able to think of the steps you made and reproduce this from the working save, would you?