I'm glad you seem to be enjoying it. It does take a bit of getting use to in comparison to vanilla science.
Yeah, the science facilities can get rather ridiculous.
It gets better once you have some stable resources coming in.
In my current Bob's Mod + Science Overhaul Mod + RSO play-through I am playing with a rather harsh modifier to science costs of 1x, 6x, 25x, 100x.
Part of me cringes at how slow I am progressing, but then again it is the first time ever that I actually can build and upgrade my factory at roughly the same pace as I research. (I am yet to skip a tier of tech entirely).
The science setup is crazy though, and I by no means have enough oil to keep it running, but at least it is large enough to ramp up if I ever manage to secure more.
(Summary: I have very high cost increase config, I built big enough to cater for late game, cannot possibly keep all running right now, but fun... I think. )
(Note: Also playing with Bob's mods, so recipes differ slightly.)
I'm starting to use coal-to-oil cracking (Bob's mods version) and that is helping. But yeah... oil... black gold... terrible and precious.